While reporting a story from India, a New York television journalist has his left hand eaten by a lion; millions of TV viewers witness the accident. In Boston, a renowned hand surgeon awaits the opportunity to perform the nation's first hand transplant; meanwhile, in the distracting aftermath of an acrimonious divorce, the surgeon is seduced by his housekeeper. A married woman in Wisconsin wants to give the one-handed reporter her husband's left hand-that...

Janelle Pruitt is into activism and causes, her former best friend Alyssa is just into herself and her "group" of self-absorbed teenagers; but then Alyssa collapses, and it turns out that diabetes has ravaged her body as badly as the recent hurricane ravaged their town and now she is in urgent need of a kidney transplant--Janelle signs up for the donor program, but when it turns out that she is an excellent match for Alyssa she is faced with a terrifying...