Oscar Wilde and the Nest of Vipers opens in the spring of 1890 at a glamorous reception hosted by the Duke and Duchess of Albemarle. All London's haut monde is there, including the Prince of Wales, who counts the Albemarles as close friends. Although it is the first time Oscar and Bertie have met, Oscar seems far more interested in Rex LaSalle, a young actor, who disarmingly claims to be a vampire... However, what begins as a diverting evening ends...